Eurobio Oncology

EndoPredict: Case study

Prof. Dr. med. Michael Untch, Head of Clinic for Gynecology, Gynecologic Oncology and Obstetrics, Head of Breast Interdisciplinary Cancer Center Department of Obstetrics and Gynecology, HELIOS Clinic Berlin-Buch in Berlin, Germany

Watch Prof. Untch’s case study

  • 43 years old, premenopausal, pT1c, N0, G2, L0, V0, R0, ER 100%, HER2-, PR 100%, Ki67 15%, early-stage breast cancer patient
  • Poll of other clinicians’ case opinions
  • How her EndoPredict result supported a confident treatment decision
  • Clinical validation of the test in this patient group
Watch Now

Get clear results

Based on her individualized risk score. See her full report

0 %

Risk of distant recurrence within 10 years

0 %

Absolute individualized chemotherapy benefit

0 %

5–15 year late distant recurrence risk*

*with 5 years of endocrine therapy alone

Have informed conversations

Simple to interpret, straightforward to explain. For example:

  • Your EndoPredict result shows that your cancer is at low risk of recurrence
  • The EndoPredict score is based on the gene activity in your cancer and its risk profile
  • There is a 92% probability your cancer will not recur within 10 years
  • Chemotherapy reduces this risk of recurrence by 2%, but this small benefit may not outweigh the potential for side effects

Make confident decisions

  • Is from the most accurate prognostic and predictive second generation test2
  • Combines her clinical factors with a molecular gene expression score, based on genes associated with early and late recurrence3-5
  • Is clinically validated and prospectively confirmed2-10
  • Includes her 15 year distant recurrence risk, providing the longest prognostic period compared to other genomic signatures4

Simple to interpret, straightforward to explain. For example:

Her report breakdown
  1. Sestak, Ivana et al. “Comparison Of The Performance of 6 Prognostic Signatures For Estrogen Receptor-Positive Breast Cancer.” JAMA Oncology, vol 4, no. 4, 2018, pp. 545–553
  2. Sestak, Ivana et al. “Prediction of chemotherapy benefit by EndoPredict in patients with breast cancer who received adjuvant endocrine therapy plus chemotherapy or endocrine therapy alone.” Breast Cancer Research and Treatment, vol. 176, 2019, pp. 377–386.
  3. Filipits, Martin et al. “Prediction of Distant Recurrence Using EndoPredict Among Women with ER+, HER2− Node-Positive and Node-Negative Breast Cancer Treated with Endocrine Therapy Only.” Clinical Cancer Research, vol. 25, no. 13, 2019, pp. 3865–3872.
  4. Filipits, Martin et al. “A New Molecular Predictor of Distant Recurrence in ER-Positive, HER2-Negative Breast Cancer Adds Independent Information to Conventional Clinical Risk Factors.” Clinical Cancer Research, vol. 17, no. 18, 2011, pp. 6012–6020.
  5. Dubsky, Peter et al. “The EndoPredict Score Provides Prognostic Information On Late Distant Metastases In ER+/HER2− Breast Cancer Patients.” British Journal Of Cancer, vol. 109, no. 12, 2013, pp. 2959–2964.
  6. Buus, Richard et al. “Comparison of EndoPredict and EPclin With Oncotype DX Recurrence Score for Prediction of Risk of Distant Recurrence After Endocrine Therapy.” Journal of the National Cancer Institute, vol. 108, no. 11, 2016, p.149.
  7. Martín, Miguel et al. “Fluorouracil, Doxorubicin, and Cyclophosphamide (FAC) Versus FAC Followed by Weekly Paclitaxel As Adjuvant Therapy for High-Risk, Node-Negative Breast Cancer: Results From the GEICAM/2003-02 Study.” Journal of Clinical Oncology, vol. 20, 2002, pp. 2593–2599.
  8. Constantinidou, Anastasia et al. “Clinical Validation of EndoPredict in Pre-Menopausal Women with ER-Positive, HER2-Negative Primary Breast Cancer.” Clinical Cancer Research, vol. 28, no. 20, 2022, pp. 4435–4443.
  9. Simon, Richard et al. “Use Of Archived Specimens In Evaluation Of Prognostic And Predictive Biomarkers.” Journal Of The National Cancer Institute, vol 101, n. 21, 2009, pp. 1446–1452
  10. Penault-Llorca, Frederique et al. “Prognostic value of EndoPredict test in patients screened for UNIRAD, a UCBG randomized, double blind, phase III international trial evaluating the addition of *** (EVE) to adjuvant hormone therapy (HT) in women with high risk HR+, HER2- early breast cancer (eBC)“. SABCS 2021, PD-09-08 Spotlight Poster Discussion 9
Prof. Dr. med. Michael Untch, Head of Clinic for Gynecology, Gynecologic Oncology and Obstetrics, Head of Breast Interdisciplinary Cancer Center Department of Obstetrics and Gynecology, HELIOS Clinic Berlin-Buch in Berlin, Germany

Watch Prof. Untch’s case study

  • 50 years old, postmenopausal, pT2, N1, G2, L0, V0, R0, ER 30/80%, PR 100/90%, Ki67 10%, lobular
    early-stage breast cancer patient
  • Poll of other clinicians’ case opinions
  • How her EndoPredict result changed the treatment decision
  • Clinical validation of the test in this patient group
Watch Now

Get clear results

Based on her individualized risk score. See her full report

0 %

Risk of distant recurrence within 10 years

0 %

Absolute individualized chemotherapy benefit

0 %

5–15 year late distant recurrence risk*

*with 5 years of endocrine therapy alone

Have informed conversations

Simple to interpret, straightforward to explain. For example:

  • Your result gave you a low-risk score
  • This is based on the activity of your genes and tumor risk profile
  • There is a 91% probability your cancer will not return within 10 years
  • Chemotherapy reduces this risk by 3%, but this small benefit may not outweigh the potential for side effects

Knowing her result

  • Is from the most accurate prognostic1 and predictive test2
  • Combines her clinical factors with a molecular gene expression score3-5
  • Is clinically validated and prospectively confirmed2-10
  • Is recommended by international guidelines11-14

Simple to interpret, straightforward to explain. For example:

Her report breakdown
  1. Sestak, Ivana et al. “Comparison Of The Performance of 6 Prognostic Signatures For Estrogen Receptor-Positive Breast Cancer.” JAMA Oncology, vol 4, no. 4, 2018, pp. 545–553
  2. Sestak, Ivana et al. “Prediction of chemotherapy benefit by EndoPredict in patients with breast cancer who received adjuvant endocrine therapy plus chemotherapy or endocrine therapy alone.” Breast Cancer Research and Treatment, vol. 176, 2019, pp. 377–386.
  3. Filipits, Martin et al. “Prediction of Distant Recurrence Using EndoPredict Among Women with ER+, HER2− Node-Positive and Node-Negative Breast Cancer Treated with Endocrine Therapy Only.” Clinical Cancer Research, vol. 25, no. 13, 2019, pp. 3865–3872.
  4. Filipits, Martin et al. “A New Molecular Predictor of Distant Recurrence in ER-Positive, HER2-Negative Breast Cancer Adds Independent Information to Conventional Clinical Risk Factors.” Clinical Cancer Research, vol. 17, no. 18, 2011, pp. 6012–6020.
  5. Dubsky, Peter et al. “The EndoPredict Score Provides Prognostic Information On Late Distant Metastases In ER+/HER2− Breast Cancer Patients.” British Journal Of Cancer, vol. 109, no. 12, 2013, pp. 2959–2964.
  6. Buus, Richard et al. “Comparison of EndoPredict and EPclin With Oncotype DX Recurrence Score for Prediction of Risk of Distant Recurrence After Endocrine Therapy.” Journal of the National Cancer Institute, vol. 108, no. 11, 2016, p.149.
  7. Martín, Miguel et al. “Fluorouracil, Doxorubicin, and Cyclophosphamide (FAC) Versus FAC Followed by Weekly Paclitaxel As Adjuvant Therapy for High-Risk, Node-Negative Breast Cancer: Results From the GEICAM/2003-02 Study.” Journal of Clinical Oncology, vol. 20, 2002, pp. 2593–2599.
  8. Constantinidou, Anastasia et al. “Clinical Validation of EndoPredict in Pre-Menopausal Women with ER-Positive, HER2-Negative Primary Breast Cancer.” Clinical Cancer Research, vol. 28, no. 20, 2022, pp. 4435–4443.
  9. Simon, Richard et al. “Use Of Archived Specimens In Evaluation Of Prognostic And Predictive Biomarkers.” Journal Of The National Cancer Institute, vol 101, n. 21, 2009, pp. 1446–1452
  10. Penault-Llorca, Frederique et al. “Prognostic value of EndoPredict test in patients screened for UNIRAD, a UCBG randomized, double blind, phase III international trial evaluating the addition of *** (EVE) to adjuvant hormone therapy (HT) in women with high risk HR+, HER2- early breast cancer (eBC)“. SABCS 2021, PD-09-08 Spotlight Poster Discussion 9
  11. Andre, Fabrice et al. “Biomarkers for Adjuvant Endocrine and Chemotherapy in Early-Stage Breast Cancer: ASCO Guideline Update.” Journal of Clinical Oncology, vol. 40, no. 16, 2022, pp. 1816–46.
  12. Cardoso, Fàtima et al. “Early breast cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up.” Annals of Oncology, vol. 30, no. 8, 2019, pp. 1194–1220.
  13. Gradishar, William et al. “NCCN Guidelines® Insights: Breast Cancer, Version 4.2021.” Journal of the National Comprehensive Cancer Network, vol. 19, no. 5, 2021, p. 484.
  14. Thomssen, Christoph et al. “St. Gallen/Vienna 2021: A Brief Summary of the Consensus Discussion on Customizing Therapies for Women with Early Breast Cancer.” Breast Care, vol. 16, 2021, pp. 135–143.
Prof. Dr. med. Michael Untch, Head of Clinic for Gynecology, Gynecologic Oncology and Obstetrics, Head of Breast Interdisciplinary Cancer Center Department of Obstetrics and Gynecology, HELIOS Clinic Berlin-Buch in Berlin, Germany

Watch Prof. Untch’s case study

  • 68 years old, pT1b (9 mm), N0, G2, L0, V0, PN0, R0, ER 100%, PR 15%, Ki67 40% early-stage breast cancer patient
  • Poll of other clinicians’ case opinions
  • How her EndoPredict result changed the treatment decision
  • Clinical validation of the test in this patient group
Watch Now

Get clear results

Based on her individualized risk score. See her full report

0 %

Risk of distant recurrence within 10 years

0 %

Absolute individualized chemotherapy benefit

0 %

5–15 year late distant recurrence risk*

*with 5 years of endocrine therapy alone

Have informed conversations

Simple to interpret, straightforward to explain. For example:

  • Your result gave you a low-risk score
  • This is based on the activity of your genes and tumor risk profile
  • There is a 19% risk your cancer will come back within 10 years, which is approximately 1 in 5
  • Having chemotherapy cuts this risk by 8%, to around 1 in 13

Make confident decisions

  • Is from the most accurate prognostic1 and predictive test2
  • Combines her clinical factors with a molecular gene expression score3-5
  • Is clinically validated and prospectively confirmed2-10
  • Is recommended by international guidelines11-16

Simple to interpret, straightforward to explain. For example:

Her report breakdown
  1. Sestak, Ivana et al. “Comparison Of The Performance of 6 Prognostic Signatures For Estrogen Receptor-Positive Breast Cancer.” JAMA Oncology, vol 4, no. 4, 2018, pp. 545-553
  2. Buus, Richard et al. “Comparison of EndoPredict and EPclin With Oncotype DX Recurrence Score for Prediction of Risk of Distant Recurrence After Endocrine Therapy.” Journal of the National Cancer Institute, vol. 108, no. 11, 2016, p.149.
  3. Filipits, Martin. “Prediction of Distant Recurrence Using EndoPredict Among Women with ER+, HER2− Node-Positive and Node-Negative Breast Cancer Treated with Endocrine Therapy Only.” Clinical Cancer Research, vol. 25, no. 13, 2019, pp. 3865–3872.
  4. Sestak, Ivana. “Prediction of chemotherapy benefit by EndoPredict in patients with breast cancer who received adjuvant endocrine therapy plus chemotherapy or endocrine therapy alone.” Breast Cancer Research and Treatment, vol. 176, 2019, pp. 377–386.
  5. Martín, Miguel. “Fluorouracil, Doxorubicin, and Cyclophosphamide (FAC) Versus FAC Followed by Weekly Paclitaxel As Adjuvant Therapy for High-Risk, Node-Negative Breast Cancer: Results From the GEICAM/2003-02 Study.” Journal of Clinical Oncology, vol. 20, 2002, pp. 2593-2599.
  6. Dubsky, Peter et al. “The Endopredict Score Provides Prognostic Information On Late Distant Metastases In ER+/HER2− Breast Cancer Patients.” British Journal Of Cancer, vol. 109, no. 12, 2013, pp. 2959-2964.
  7. Penault-Llorca, Frederique et al. “Prognostic value of EndoPredict test in patients screened for UNIRAD, a UCBG randomized, double blind, phase III international trial evaluating the addition of *** (EVE) to adjuvant hormone therapy (HT) in women with high risk HR+, HER2- early breast cancer (eBC)“. SABCS 2021, PD-09-08 Spotlight Poster Discussion 9
  8. Constantinidou, Anastasia. “Clinical Validation of EndoPredict in Pre-Menopausal Women with ER-Positive, HER2-Negative Primary Breast Cancer.” Clinical Cancer Research, vol. 28, no. 20, 2022, pp. 4435-4443.
  9. Vázquez-Juarez, Daniela et al. ”Follow-up of prospective cohort of Mexican premenopausal women with breast cancer who received guided adjuvant treatment with the EndoPredict assay.” SABCS 2021, P4-05-15
  10. Klein, Evelyn et al. “Abstract Reports: Long-term outcome data using Endopredict® as risk stratification and chemotherapy decision biomarker in hormone receptor positive, HER2-negative early breast cancer.” Cancer Research, 83, no.5S, pp01-24
  11. Andre, Fabrice et al. “Biomarkers for Adjuvant Endocrine and Chemotherapy in Early-Stage Breast Cancer: ASCO Guideline Update.” Journal of Clinical Oncology, vol. 40, no. 16, 2022, pp. 1816-46.
  12. Cardoso, Fàtima et al. “Early breast cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up.” Annals of Oncology, vol. 30, no. 8, 2019, pp. 1194-1220.
  13. Gradishar, William et al. “NCCN Guidelines® Insights: Breast Cancer, Version 4.2021.” Journal of the National Comprehensive Cancer Network, vol. 19, no. 5, 2021, p. 484.
  14. Thomssen, Christoph et al. “St. Gallen/Vienna 2021: A Brief Summary of the Consensus Discussion on Customizing Therapies for Women with Early Breast Cancer.” Breast Care, vol. 16, 2021, pp. 135-143.
  15. Giuliano, Armando et al. “Breast Cancer–Major changes in the American Joint Committee on Cancer eighth edition cancer staging manual,” CA: A Cancer Journal for Clinicians, vol. 67, 2017, p. 290-303
  16. National Institute for Health and Care Excellence. “Tumour profiling tests to guide adjuvant chemotherapy decisions in early breast cancer: Diagnostics guidance,” 2018

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