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High-sensitivity donor-recipient chimerism monitoring can aid in the diagnosis of leukemia relapse and facilitate timely clinical intervention. Our KMRtype kits can be used to determine presence or absence of genetic markers for chimerism monitoring. By using the qPCR technique, a sensitivity of as low as 0.05% can be reached (20 to 100 fold more sensitive compared to current conventional method using STRs). After genotyping with KMRtype, the KMRtrack kit can be used for monitoring. Both KMRtype and KMRtrack kits are available as RUO and CE-marked IVD.
Monitoring kit to track chimeric status in time Available as RUO…
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When relapse is detected after HLA-mismatched hematopoietic stem cell transplantation (HSCT), it is important to understand whether or not it is characterized by “HLA loss”, i.e. genomic loss of the mismatched HLA, as this has important implications for the appropriate treatment options. The HLA-KMR kit contains 10 markers to detect HLA loss relapse. The 10 genomic markers are all located within HLA genes and integrated in the KMRtype/KMRtrack and KMRengine workflow. Available as RUO.
HLA loss detection assays Available as RUO
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KMRengine is our highly intuitive software for the chimerism monitoring workflow. KMRengine guides you through the entire workflow, from genotyping to monitoring, from the first time point to the most recent time point of monitoring. Available as RUO and CE-marked IVD.
Analysis software for qPCR-based chimerism monitoring (KMRtype, KMRtrack and HLA-KMR…
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KMRassay qPCR Buffer & Enzyme contains the necessary buffer and enzyme for the performance of KMRtype and KMRtrack. Available as RUO and CE-marked IVD.
qPCR Buffer & Enzyme
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KMRassay Reference Assay 901 contains the necessary genetic reference for the performance of KMRtype and KMRtrack. This assay targets a housekeeping gene outside the HLA region and has been designed to give a positive result for all human DNA. Available as RUO and CE-marked IVD.
Reference Assay 901
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NGSgo-AmpX v2 and v3 kits for long-range HLA gene amplification, compatible with Illumina and Ion Torrent sequencing platforms
Singleplex HLA amplification 11 loci
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EBX-042 EurobioPlex FluCoSyn molecular biology reagent kit
EurobioPlex FluCoSyn is a test using reverse-transcription and real-time amplification…
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EBX-041 Eurobioplex SARS-CoV-2 multiplex molecular biology reagent kit
The EurobioPlex SARS-CoV-2 assay is a test using reverse-transcription and…
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The EurobioPlex Flu A/Flu B/SARS-CoV-2 is a test for the…
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The EurobioPlex SARS-CoV-2 Fast-SVT test is a real-time polymerase chain…
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