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NGS-Turbo prep and TurboAmp kits for 11-loci HLA typing using Oxford nanopore sequencing
NGS-Turbo®
Complete mono-sample solution for Oxford Nanopore sequencing
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NGS-Pronto prep and ProntoAmp kits for 11-loci HLA typing using nanopore sequencing
NGS-Pronto®
Complete solution for Oxford Nanopore sequencing
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NGSgo MX6-1 kit for 6-loci HLA typing in a single tube, compatible with Illumina and PacBio sequencing platforms
NGSgo®-MX6-1
Multiplexed HLA amplification 6 loci
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MX11-3 11 loci multiplex amplification for Illumina, Ion Torrent, PacBio
NGSgo®-MX11-3
Compatible with Illumina and PacBio sequencing systems.
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NGSgo-AmpX v2 and v3 kits for long-range HLA gene amplification, compatible with Illumina and Ion Torrent sequencing platforms
NGSgo®-AmpX v2/AmpX v3
Singleplex HLA amplification 11 loci
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NGSgo Library Full Kit by GenDx with reagent bottles, color-coded tubes, PCR plate, and packaging for NGS library preparation workflows
NGSgo® Library Full Kit
Library preparation and indexing kit
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NGSengine®
Analysis software for NGS-based typing
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NGStrack® NGS chimerism monitoring kit by GenDx for highly sensitive post-transplant surveillance
NGStrack®
Chimerism monitoring by NGS (assay) Available as RUO
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High-sensitivity donor-recipient chimerism monitoring can aid in the diagnosis of leukemia relapse and facilitate timely clinical intervention. Our KMRtype kits can be used to determine presence or absence of genetic markers for chimerism monitoring. By using the qPCR technique, a sensitivity of as low as 0.05% can be reached (20 to 100 fold more sensitive compared to current conventional method using STRs). After genotyping with KMRtype, the KMRtrack kit can be used for monitoring. Both KMRtype and KMRtrack kits are available as RUO and CE-marked IVD.
KMRtype®
Genotyping kit to select informative markers for chimerism monitoring Available as RUO & CE-IVD
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High-sensitivity donor-recipient chimerism monitoring can aid in the diagnosis of leukemia relapse and facilitate timely clinical intervention. Our KMRtype kits can be used to determine presence or absence of genetic markers for chimerism monitoring. By using the qPCR technique, a sensitivity of as low as 0.05% can be reached (20 to 100 fold more sensitive compared to current conventional method using STRs). After genotyping with KMRtype, the KMRtrack kit can be used for monitoring. Both KMRtype and KMRtrack kits are available as RUO and CE-marked IVD.
KMRtrack®
Monitoring kit to track chimeric status in time Available as RUO & CE-IVD
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When relapse is detected after HLA-mismatched hematopoietic stem cell transplantation (HSCT), it is important to understand whether or not it is characterized by “HLA loss”, i.e. genomic loss of the mismatched HLA, as this has important implications for the appropriate treatment options. The HLA-KMR kit contains 10 markers to detect HLA loss relapse. The 10 genomic markers are all located within HLA genes and integrated in the KMRtype/KMRtrack and KMRengine workflow. Available as RUO.
HLA-KMR®
HLA loss detection assays Available as RUO
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KMRassay qPCR Buffer & Enzyme contains the necessary buffer and enzyme for the performance of KMRtype and KMRtrack. Available as RUO and CE-marked IVD.
KMRassay qPCR buffer & Enzyme
qPCR Buffer & Enzyme
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KMRassay Reference Assay 901 contains the necessary genetic reference for the performance of KMRtype and KMRtrack. This assay targets a housekeeping gene outside the HLA region and has been designed to give a positive result for all human DNA. Available as RUO and CE-marked IVD.
KMRassay™ Reference Assay 901
Reference Assay 901
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Chimerism monitoring by NGS is the latest development in post-transplantation surveillance and replaces the less sensitive conventional STR (short tandem repeat) method because of its higher sensitivity (2-10 times more sensitive). GenDx is offering a solution for Chimerism monitoring by NGS, NGStrack® (assay) & TRKengine® (software). NGStrack results can be visualized with TRKengine, our in-house developed software, based on the best features of our renowned NGSengine® and KMRengine® software packages that have been perfected for over a decade. NGStrack and TRKengine are available as RUO.
TRKengine®
Chimerism monitoring by NGS (software)
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KMRengine is our highly intuitive software for the chimerism monitoring workflow. KMRengine guides you through the entire workflow, from genotyping to monitoring, from the first time point to the most recent time point of monitoring. Available as RUO and CE-marked IVD.
KMRengine®
Analysis software for qPCR-based chimerism monitoring (KMRtype, KMRtrack and HLA-KMR assays)
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NGSgo®-AmpX KIR
Allele-level KIR typing by NGS
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